中文摘要：

目的：探讨RhoE在胃癌、结肠癌以及相应癌旁组织中的表达情况及临床意义。方法：采用免疫组化的方法检测74例胃癌，32例结肠癌及相应癌旁组织中RhoE的表达水平。结果：RhoE在胃肠道正常组织中普遍表达，在腺体中尤为明显，但在肿瘤组织表达低下或缺失。RhoE在胃癌组织中的染色平均值为1．99±0．28，在相应癌旁组织中为8．64±0．39，明显高于相应肿瘤组织（P〈0．005），并且随着肿瘤分化程度的降低染色强度有下降的趋势（P〈0．005）。RhoE在32例结肠癌组织中的染色平均值为2．45±0．35，在相应癌旁组织中为6．55±0．63，明显高于相应肿瘤组织（P〈0．005），同样有染色强度随着肿瘤分化程度的降低而降低的趋势（P〈0．005）。结论：RhoE在肿瘤组织中表达明显下降，表明它在肿瘤的发生发展中起着重要的负性调控作用，结合最新的研究成果我们推断RhoE很可能是一个重要的抑癌基因。

英文摘要：

Objective： To investigate the expression and clinical significance of RhoE in gastrointestinal （GI） carcinoma as well as the corresponding adjacent tissues. Methods： The expression of RhoE was detected by immuno-histochemistry in 74 samples of gastric carcinoma and 32 samples of colon carcinoma, and their corresponding adjacent tissues were taken as control. Results： RhoE was generally expressed in normal gastrointestinal tissues, especially in glands. But its expression level in cancerous tissues was decreased or absent. The stained value for gastric carcinoma was 1.99±0.28, but the adjacent cancerous tissues was 2.45±0.35, significantly higher than that of the adjacent cancerous tissues （ P 〈 0.005）. Moreover, there is a declining tendency of the stained value as the poor differentiation of the carcinoma （ P 〈 0. 005 ）. The stained value for colon carcinoma was 2.45 ± 0.35, lower than that of the adjacent cancerous tissues （6.55 ± 0.63, P 〈 0.005 ）. There was also a declining tendency of the stained value as well as gastric carcinoma（ P 〈0. 005 ）. Conclusion： The expression of RhoE is significantly decreased in the samples of gastrointestinal carcinoma. So it suggested that RhoE may play a negative role in the generation and development of GI cancer. With the recent research outcomes, RhoE might be an important candidate for tumor supressor gene.