线粒体含有约1000种蛋白质,其中99%由细胞核DNA编码,在细胞质核糖体上合成后被分别转运至线粒体的内膜或外膜上、基质或膜间隙中。由众多分子机器组成的线粒体蛋白质转运系统参与了该生物学过程的执行。线粒体DNA编码的13种蛋白质也由该系统转运至线粒体内膜。本文就线粒体蛋白质转运系统中线粒体前体蛋白质的定位分选信号、转运复合物和转运途径作简要介绍。
There are about 1000 proteins located in mitochondria, of which 99% are encoded by nucleic DNA, synthesized by cytosolic ribosomes and then imported into one of the four mitochondrial compartments:matrix, inner membrane, intermembrane space and outer membrane.Several intricate molecular machines are dedicated to catalyze these processes as the mitochondrial protein translocation system.Thirteen proteins encoded by mitochondrial DNA are also translocated into inner membrane by this system.The various targeting signals of mitochondrial precursors, translocase complexes and mitochondrial protein translocation pathways will be described in the review.