中文摘要：

目的 探讨飞秒激光2,0 mm微切口角膜基质透镜取出术（MILE）临床矫正近视、散光的效果及该微创屈光手术的可行性.方法 前瞻性病例对照研究.入选接受MILE的患者61例,另3.0～5.0 mm小切口角膜基质透镜取出术（SMILE）的患者53例作为对照.飞秒激光系统透镜成型并设置为2.0 mm或3.0～5.0 mm切口取出.术前及术后1d、1周、1个月、6个月均进行UCVA、BCVA、屈光度数、眼压、眼前节和角膜地形图等检查.采用重复测量方差分析两组手术之间、手术前后屈光度和形态学参数之间的差异;应用配对t检验分析各组手术前后各时间点之间屈光度和形态学参数的统计学差异;应用独立样本t检验比较两组术前基本资料以及手术前后各对应时间点的屈光度和形态学参数之间的差异.结果 MILE组随访资料完整者共24例（41只眼）,SMILE组共29例（51只眼）.在术前及术后1d、1周、1个月、6个月,MILE组球镜度数分别为（-5.09±1.04）、（0.12±0.32）、（0.11±0.29）、（0.02 ±0.33）、（0.02 ±0.23）D;柱镜度数分别为（-0.90 ±0.83）、（-0.25 ±0.27）、（-0.23 ±0.30）、（-0.20 ±0.25）、（-0.16 ±0.21）D;SMILE组的球镜度数分别为（-5.37±1.26）、（-0.04 ±0.49）、（0.12±0.38）、（0.10±0.34）、（0.02±0.33）D;柱镜度数分别为（-0.76±0.65）、（-0.22±0.26）、（-0.25±0.30）、（-0.26 ±0.29）、（-0.21±0.28）D,两组等效球镜、球镜与柱镜度数之间的差异均无统计学差异（F=1.042、0.941、0.018,P＞0.05）.在散光的矢量分析结果中,MILE组在术后1和6个月Y轴方向的散光度数分别为（-0.06 ±0.11）、（-0.04±0.10）D,SMILE组为（-0.14±0.18）、（-0.11±0.16）D,MILE组小于SMIIE组（Z=-2.076、-2.149,P＜0.05）.术后6个月,100％的患者UCVA≥1.0.术后6个月无一例出现BCVA的降低.1个月内达到相对稳定的屈光状态,且较SMILE组具有更小的波动性.在术前及术后1d、1周、1

英文摘要：

Objective To report the clinical results of micro incision lenticule extraction （MILE） to correct myopia or myopia with astigmatism,and enlighten its viability and mechanism.Methods Prospective case-control study.All patients enrolled were treated by the VisuMax femtosecond laser system to correct refractive errors.Sixty-one patients underwent MILE with an incision of 2 mm.Another 53 patients underwent small incision lenticule extraction （SMILE） with a 3-5 mm incision as the control group.All patients took measurements of uncorrected visual acuity （UCVA）,best corrected visual acuity （BCVA）,refractive power and intraocular pressure,slit-lamp microscopy,and corneal topography preoperatively and at 1 day,1 week,1 month,6 months postoperatively.The visual acuity was presented as median.To compare the visual acuity and astigmatism between the MILE group and the SMILE group,as well as before surgery and at each time point after surgery,non-parametric tests were applied in this study.The repeated measures analysis of variance was used to compare the differences between these two surgeries and between pre-and post-operation in diopters and morphological parameters.The paired-sample t test was used to compare the diopters and morphological parameters at each time point postoperatively and preoperatively.The independent-sample t test was applied to compare the basic characteristics preoperatively and the diopters,morphological parameters at each time point between these two groups.Results Forty-one eyes （24 patients） in the MILE group and fifty-one eyes （29 patients） in the SMILE group had complete follow-up data.Before surgery and at 1 day,1 week,1 month,6 months after surgery,the spherical diopters in the MILE group were （-5.09 ± 1.04）,（0.12 ± 0.32）,（0.11 ± 0.29）,（0.02 ± 0.33） and （0.02 ± 0.23） D ; the cylinder diopters were （-0.90 ± 0.83）,（-0.25 ± 0.27）,（-0.23 ± 0.30）,（-0.20 ± 0.25） and （-0.16 ±0.21）D.In the SMILE group,the spherical diopters were