以没食子酸为先导,经甲基醚化、无溶剂闭环、缩合反应合成了8个未见文献报道的1,2,4-三唑并[3,4-b]-1,3,4-噻二唑类衍生物,其结构经1H NMR,13C NMR,IR和元素分析表征。初步生物活性测试结果表明,部分化合物具有一定的抗黄瓜花叶病毒活性。
Eight novel triazolo[3,4-b]-1,3,4-thiadiazole derivatives were synthesized from gallic acid by methyl etherification,closed loop in solvent-free and condensation reaction.Their structures were characterized by 1H NMR,13C NMR,IR and elemental analysis.The preliminary bioassay showed that some of them exhibited certain antivirus activity against Cucumber mosaic virus.