中文摘要：

Chemoresistance 堵住上皮的卵巢的癌症的有效治疗，它所有妇产科的癌症是最致命的。癌症干细胞被相信是至少为 chemoresistance 的发展部分负责。在这研究，癌症的丰富和增长上的 cisplatin (CDP ) 的效果像茎的房间(CSLC ) 被调查，并且行动的内在的机制被阐明。一在里面 vitro 没有锚的系统被采用从 SKOV3 人的上皮的卵巢的癌症房间线充实 CSLC。我们的结果证明有 CDP 的低集中的治疗导致了更好充实的 CSLC，与更高的 proliferative 活动。CDP 的低剂量被发现导致 chemokine (C-X-C 主题) 的表示受体 4 (CXCR4 ) ，它为卵巢的癌症治疗是在癌症干细胞以及一个有希望的治疗学的目标的一个重要 stemness 标记。结果也证明 overexpressed CXCR4 产生了 chemoresistance。把结果基于这些，在低集中， CDP 本身贡献药抵抗的发展，这可以被结束。这发现提供新奇卓见进位于 chemoresistance 下面的机制并且为上皮的卵巢的癌症治疗有重要治疗学的含意。

英文摘要：

Chemoresistance blocks the efficient treatment of epithelial ovarian cancer, which is the most lethal of all gynecological cancers. Cancer stem cells are believed to be at least partially responsible for the development of chemoresistance. In this study, the effect of cisplatin （CDP） on the enrichment and proliferation of cancer stem-like cells （CSLCs） was investigated, and the underlying mechanisms of action were elucidated. An in vitro anchor-free system was employed to enrich CSLCs from the SKOV3 human epithelial ovarian cancer cell line. Our results showed that treatment with low concen- trations of CDP resulted in better-enriched CSLCs, with higher proliferative activities, Low dose of CDP was found to induce the expression of chemokine （C-X-C motif） receptor 4 （CXCR4）, which is an important stemness marker in cancer stem cells as well as a promising therapeutic target for ovar- ian cancer treatment. Results also showed that overexpressed CXCR4 generated chemoresistance. Based on these results, it may be concluded that, at low concentrations, CDP itself contributes to the development of drug resistance. This finding provides novel insight into the mechanisms underlying chemoresistance and has significant therapeutic implications for epithelial ovarian cancer treatment.