中文摘要：

细胞穿透肽是一类少于30个氨基酸的短肽，它们能穿过细胞膜并携带各种“货物”包括小分子、蛋白、肽、核酸等进入细胞，而发挥“货物”的生物学作用。其转导机制一直是研究的热点，至今仍不明确。本文讨论直接入胞、转导、内吞3种可能的穿膜机制及其特点。

英文摘要：

Cell-penetrating peptides are relatively short domain of the peptides sequence （fewer than 30 amino acid residue ）. They can cross cell membranes and deliver a large variety of biological cargoes, such as small particles, protein, peptides, and nucleic acids, and induce the biological effects of cargoes. The uptake mechanism of cell-penetrating peptides is currently a topic of heated discussion, which is not clear yet. This review briefly discusses 3 possible uptake mechanisms and the characteristics： direct penetration into the membrane, transloeation through formation of a transient structure, endocytosis-mediated entry.