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中文摘要：
胞外信号调控激酶（ERK）是发现的第1个丝裂原活化蛋白激酶（MAPK），它调控多种重要的细胞生物学过程，包括细胞增殖、分化和凋亡等。ERK信号级联反应能够特异地介导广泛的生物学过程，其机制主要是通过信号的反馈调控，与支架蛋白的相互作用，亚细胞定位的改变，在级联反应的每一个环节存在不同功能的多种组分，细胞内非磷酸酶抑制物和G蛋白等的调控实现的。
英文摘要：
Extracellular signal-regulated kinase （ERK）, the first mitogen-activated protein kinase （MAPK） to be identified, controls many kinds of important cell biological processes, such as cell proliferation, differentiation, apoptosis and more. MAPK signal cascade specificully regulates various biological processes, the mechanisms of which including regulation by feedback loops, interaction with specific scaffold proteins, changes in subcellular localization, presence of multiple components with distinct functions in each tier of the cascade, nonphosphatase inhibitors of ERK signaling and G protein.
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