中文摘要：

目的观察丙泊酚在中脑导水管周围灰质腹外侧区（vlPAG）诱发的痛觉过敏是否通过延髓头端腹内侧核群（RVM）的GABAA受体介导。方法采用热板法和福尔马林试验,将大鼠随机分组,丙泊酚和荷包牡丹碱分别采用vlPAG和RVM置管及微量注射给药。分别以舔后爪潜伏时间和疼痛评分为痛阈指标。结果两种疼痛模型中丙泊酚在vlPAG微量注射后（丙泊酚组）均引起痛觉过敏（P〈0.01）,预先在RVM注射荷苞牡丹碱（丙泊酚＋荷包牡丹碱组）可部分拮抗这种作用。结论丙泊酚在vlPAG引起痛觉过敏,这种作用部分是通过RVM的GABAA受体中继而发挥作用的。

英文摘要：

Objective To observe whether the propofol-induced hyperalgesia at ventrolateral portion of the PAG（ vlPAG） is mediated by GABAA receptor at rostral ventromedial medulla （ RVM） of rats. Methods SD rats were randomly divided into four groups. The noxious response was evaluated by hot plate and formalin test. Bicuculline and propofol were separately microinjected into RVM and vlPAG. Results Hyperalgesia were induced in both hot-plate test and formalin test after propofol vlPAG microinjection. The hyperalgesia induced by propofol vlPAG microinjection was antagonized by bicuculline RVM microinjection （ P 0. 01） . Conclusion GABAA receptor in the rostral ventromedial medulla （ RVM） partially mediates propofol-induced hyperalgesia at ventrolateral portion of the PAG（ vlPAG） of rats.