中文摘要：

目的：研究寻常型银屑病病人血清中肿瘤坏死因子-α、白细胞介素-8（TNF-α、IL-8）的表达,探讨TNF-α、IL-8在寻常型银屑病中的作用。方法：采用双抗体夹心ELISA法检测29例寻常型银屑病病人和31例健康志愿者血清TNF-α、IL-8的水平。组间均数比较利用成组t检验进行统计分析。TNF-α、IL-8表达水平关系利用线性回归分析。结果：银屑病组TNF-α、IL-8水平显著增高,与健康对照组相比差异均有统计学意义（P〈0.05）,并且TNF-α、IL-8血清中表达水平呈正相关（P〈0.01,R=0.812）。结论：TNF-α、IL-8在银屑病的发病中可能发挥着重要作用。

英文摘要：

Objective：To detect the serum levels of TNF-α and IL-8 in patients with psoriasis vulgaris,and to investgate the ralationship between cytokines and the disease. Methods：Serum levels of TNF-α,IL-8 were detected in 29 patients with psoriasis vulgaris and 31 health controls by enzyme linked immunosorbent assay（ ELISA） . Independent samples t-test and linear regression analysis were used in statistic analysis. Results：Compared with control group,both surem levels of TNF-α and IL-8 in patients with psoriasis vulgaris were increased significantly （ P〈0 . 05 ） . The level of TNF-α was correlated with IL-8（P〈0. 01,R=0. 812）. Conclusion：TNF-α and IL-8 may play an important role in the pathogenesis of psoriasis vulgaris.