脂氧素( lipoxins,LXs)是Serhan等[1]在1984年首次发现的一类具有三羟四烯结构的花生四烯酸代谢产物,已被证实是炎症反应的强大的"停止信号"[2]。 LXs参与很多疾病,尤其是消化系统疾病的病理生理过程,其多种生物学作用,尤其是抗炎促消退作用为消化系统疾病的治疗提供了新的思路。现就LXs在消化系统疾病中的作用综述如下。
Lipoxins, metabolites of arachidonic acid , are a strong"braking signal" towards inflammatory reac-tion.Due to their anti-inflammatory and pro-resolving properties , lipoxins have emerged to be the central targets in the re-search on inflammation .The present article reviews the research advances of synthesis , biological effects and the protective role of lipoxins in the diseases of liver , pancreas , stomach and colorectum , thus providing a novel approach for the treat-ment of digestive diseases .