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急性胸痛早期鉴别和危险分层的生物标志物检测
  • ISSN号:1009-9158
  • 期刊名称:《中华检验医学杂志》
  • 时间:0
  • 分类:R542.22[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:山东大学齐鲁医院急诊科、胸痛中心,山东大学急危重症医学研究所,山东省卫生系统急危重症医学重点实验室,教育部、卫生部心血管重构与功能研究重点实验室,山东济南250012
  • 相关基金:国家自然科学基金(81100147,81571934);山东省泰山学者建设工程专项经费(ts20130911);山东省科技惠民计划项目(2014kjhm0102);山东省科技发展计划项目(2014GGE27492)Fund program:National Natural Science Foundation of China,Special Fund for Construction Project of Taishan Scholars in Shandong Province,Shandong Provincial Science and Technology People Benefit Management Plan,Development and Plan Projects of Science and Technology of Shandong Province of China
中文摘要:

外伤性心肌梗死(TMI)是指在受到创伤或打击后出现心电图异常变化和心肌血清酶学或肌钙蛋白升高,并符合急性心肌梗死(AMI)动态演变的疾病。交通事故导致的心脏钝挫伤(BCI)发生TMI的风险较大。TMI的发病机制可能为外伤导致冠状动脉(冠脉)内膜破裂、夹层;已知粥样硬化斑块破裂;冠脉痉挛或破裂;外部血肿压迫冠脉;创伤后应激状态促进血栓形成等。TMI临床表现不典型,但心电图和心肌酶学指标可见动态变化。在治疗上,目前认为早期再灌注治疗可有效挽救濒死心肌,并改善心功能。经皮冠脉介入治疗(PCI)仍是TMI的首选治疗方式,但应充分考虑出血风险,制定个体化治疗方案。结合国内外发表的相关文献,从TMI的发病机制、临床特征、诊断及鉴别诊断、治疗等方面进行综述,为促进TMI临床诊治及进一步开展相关研究提供参考。

英文摘要:

The traumatic myocardial infarction (TMI) refers to the abnormal electrocardiogram changes and myocardial enzymology or serum troponin rise, and it is in line with the dynamic evolution of acute myocardial infarction (AMI) disease after trauma. Studies have shown that blunt cardiac injury (BCI) caused by traffic accident is at a higher risk factor of developing TMI. The pathogenic mechanisms of TMI usually consists of the following aspects: trauma caused coronary artery inner rupture or dissection; atherosclerotic plaque rupture; coronary spasm or rupture; external hematoma squeeze coronary artery; post traumatic stress state promoted thrombosis. The clinical manifestation of TMI is not typical, but its electrocardiogram and myocardial enzymology indexes show dynamic changes. A current view on the treatment of TMI is that early reperfusion therapy can effectively save the dying myocardium, and improve cardiac function. Percutaneous coronary intervention (PCI) is still the first choice for treatment of TMI, but hemorrhagic risk should be considered sufficiently, and it is necessary to establish a personalized treatment plan. We reviewed and summarized the relevant literature published both at home and abroad with focus on the pathogenic mechanisms of TMI, and on its clinical features, diagnosis and treatment in order to provide the reference for further research and clinical treatment of TMI.

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期刊信息
  • 《中华检验医学杂志》
  • 中国科技核心期刊
  • 主管单位:中国科协
  • 主办单位:中华医学会
  • 主编:
  • 地址:北京市东四西大街42号
  • 邮编:100710
  • 邮箱:office@cma.org.cn
  • 电话:010-85158180
  • 国际标准刊号:ISSN:1009-9158
  • 国内统一刊号:ISSN:11-4452/R
  • 邮发代号:2-71
  • 获奖情况:
  • 1998年获中国科协优秀期刊三等奖,中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:36520