中文摘要：

分子印迹聚合物是一种模仿天然分子识别系统的合成材料,对模板分子有特异选择性和亲和力.若以手性药物的单对映体为模板制备分子印迹聚合物,会因其特殊的三维空腔结构而展现出对映体选择性识别的能力,故在手性药物应用研究领域发展迅速.本文综述了近年来将分子印迹聚合物用作手性固定相进行手性药物拆分,以及作为辅料用于对映体选择性智能释药系统的研究进展.

英文摘要：

Molecular imprinted polymers （MIPs） with high selectivity and affinity for the template molecules are synthetic materials which mimic natural molecularly recognition system. MIPs prepared by the single enantiomer as template show enantioselective recognition capabilities due to their special structures of the three-dimensional cavities, and the applied research in the field of chiral drugs have been developed rapidly. This paper provides an overview on the recent advances in applications of MIPs to chiral stationary phases for the enantioseparation of chiral drugs, as well as the usage for the enantioselective intelligent drug delivery systems as excipients.