中文摘要：

目的评价改良阴茎海绵体压力（intracavemouspressure，ICP）测定方法在建立糖尿病性勃起功能障碍（erectiledysfunction，ED）大鼠模型中的应用。方法将40只8周龄雄性sD大鼠随机分为糖尿病组及正常对照组，检测大鼠ICP及颈动脉压力（arterialpressure，AP），改良法采用带倒刺的穿刺针刺入阴茎脚。结果在糖尿病组及正常对照组中，与传统方法比较，采用改良阴茎海绵体压力测定方法所测的ICP与AP结果均无统计学意义（P〉0．05），但改良法穿刺针不易脱出，保证了实验顺利进行，成功率大大提高（传统法成功率75％，改良法100％）。结论改良的带倒刺的穿刺针刺入阴茎脚测定大鼠阴茎海绵体压力具有稳定、准确、方便和不易脱出的特点，对筛选糖尿病性ED大鼠动物模型、评价大鼠阴茎勃起功能具有重要意义。

英文摘要：

Objective To evaluate the modified method of intracavemous pressure（ICP） monitoring in establishing rat model with diabetic erectile dysfimction. Methods Forty male rats were randomized equally into 2 groups （control group and diabetic group）. ICP and arterial pressure （AP） were monitored with the improved method and the traditional method, respectively. The modified method used improved intravenous infusion needle puncture in the crus of penis. Results There was no significant difference in measurement of the ICP and AP between the modified method and the traditional method （P〉 0.05 ）, both in the control group and diabetic group. The modified method used improved intravenous infusion needle puncture in the crus of penis can improve the success rate significantly （the traditional method being 75% and the modified method being 100%）. Conclusion The modified method of intracavemous pressure monitoring has characteristic of stable ,accurate,higher success rate. It is of great significance for establishing rat model with diabetic erectile dysfunction and evaluating rat penile erectile function.