中文摘要：

目的通过壳聚糖衍生物表面的巯基与金元素形成非常强的Au—S键，制备表面带有金纳米棒（GNRs）的白组装纳米球CS-GNRs。方法用透射电子显微镜观察自组装纳米球的形貌特征，动态激光粒度分析仪检测其粒度分布，紫外一可见分光光度计检测其光学特性及其性质改变，同时对其表面增强拉曼光谱（SERS）效应进行检测。结果该纳米球形态良好、粒径均一、分散性好，并且结晶紫（CV）在壳聚糖纳米金杂化纳米球表面的拉曼增强因子可达2×10^3。结论该纳米球在分子检测和拉曼光谱效应检测方面具有潜在的应用价值。

英文摘要：

Objective To prepare self-assembled thiolated chitosan derivatives gold nanoparticles （CS- GNRs） and carry out the feature tests. Methods CS-GNRs was prepared by chitosan derivatives and GNRs through strong metal sulfur chemical bond between thiols and gold on GNRs surface. Morphology features was tested by transmission electron microscope, dynamic light scattering was adopted to observe the size of nanoparticles. Ultraviolet-visible spectrophotometer was used to detect the optical properties and the property change. Meanwhile, the surface-enhanced Raman scattering （SERS） activity of CS-GNRs was investigated by using crystal violet （CV） as a probe molecular. Results CS-GNRs were in good shape, uniform particle size and good dispersion. The SERS of CV was enhanced, and the enhancement factor of CV adsorbed on CS-GNRs was up to 2×10^3. Conclusions The nanoparticles have potential application in molecular detection and Raman spectra detection.