目的分析有家族史和无家族史寻常型银屑病患者在发病年龄、发病季节、病情严重程度及发病部位等表型上的不同。方法采用问卷调查形式对210例有家族史寻常型银屑病患者和780例无家族史该病患者进行调查,用EPI和SPSS软件对资料进行分析。结果有家族史寻常型银屑病患者较无家族史该病患者发病年龄早(t=3.585,P=0.000),在夏季的发病频率低(x^2=6.458,P=0.011),病情较轻(x^2=12.712,P=0.002),较少累及到臀部(x^2=8.059,P=0.005)、胸部(x^2=5.235,P=0.022)、腹股沟(x^2=7.496,P=0.006)、颈部(x^2=6.515,P=0.011)、腋下(x^2=9.594,P=0.002)、外生殖器(x^2=4.813,P=0.028)和甲(x^2=5.735,P=0.017)部位。结论有家族史和无家族史寻常型银屑病患者在某些表型上差异有显著性,可能具有不同的遗传学基础。
Objective To explore some differences in phenotypes between familial and sporadic psoriasis vulgaris. Methods Data collected from 210 familial patients and 780 sporadic patients with psoriasis vulgaris were analyzed by EPI and SPSS software. Results Familial psoriasis patients had earlier age of onset ( t = 3. 585, P = 0.000) , lower onset frequency in summer (X^2 = 6. 458, P = 0. 011 ), milder clinical manifestation (X^2 = 12. 712, P = 0. 002) ; more affected buttocks (X^2 = 8. 059, P = 0. 005 ), thorax (X^2 = 5. 235, P = 0. 022), groin (X^2 = 7. 496, P=0.006), neck (X^2 =6.515, P=0.011), oxter (X^2 =9.594, P=0.002), anogenital area (X^2 =4.813, P= 0. 028) and nail (X^2 = 5.735, P = 0. 017 ). Conclusion It seems that familial and sporadic psoriasis has quite different phenotypes and may have different genetic basis.