中文摘要：

先进年龄是为年龄相关的复杂疾病的一个独立风险因素，例如冠的动脉疾病，击，和高血压，它是普通的但是威胁的生活并且与联系年龄的脉管的机能障碍有关。在另一方面，有早衰症候群的病人受不了严肃的动脉粥样硬化，建议损害脉管的功能可能对 organismal 变老批评，或反过来也如此。然而，它仍然保持大部分未知怎么脉管的房间，特别地 endothelial 房间，变得衰老并且老朽怎么损害脉管的功能并且随着时间的过去贡献年龄相关的脉管的疾病。这里，我们在脉管的变老和 endothelial 房间老朽 invitro 和 invivo 的特征上考察最近的进步，评估怎么基因，象 autophagy 和干细胞一样的环境因素影响 endothelial 房间老朽并且老朽怎么贡献年龄相关的脉管的显型，例如动脉粥样硬化和增加的脉管的僵硬，并且探索可能性我们是否能通过脉管的变老的控制推迟年龄相关的脉管的疾病。

英文摘要：

Advanced age is an independent risk factor for ageing-related complex diseases, such as coronary artery disease, stroke, and hypertension, which are common but life threatening and related to the ageing-associated vascular dysfunction. On the other hand, patients with progeria syndromes suffer from serious atherosclerosis, suggesting that the impaired vascular functions may be critical to organismal ageing, or vice versa. However, it remains largely unknown how vascular cells, particularly endothelial cell, become senescent and how the senescence impairs the vascular functions and contributes to the age-related vascular diseases over time. Here, we review the recent progress on the characteristics of vascular ageing and endothelial cell senescence in vitro and in vivo, evaluate how genetic and envi- ronmental factors as well as autophagy and stem cell influence endothelial cell senescence and how the senescence contributes to the age- related vascular phenotypes, such as atherosclerosis and increased vascular stiffness, and explore the possibility whether we can delay the age-related vascular diseases through the control of vascular ageing.