中文摘要：

疱疹单一的病毒类型 1 (HSV-1 ) 感染房间的蛋白质(ICP27 ) 27 是在感染期间涉及 HSV-1 基因规定的各种各样的步以及在主人基因表达的用以遮闭之物的必要、高度保存的蛋白质。它在禁止拼接的先锋信使 rna 并且在支持病毒的抄本的原子出口首先在 post-transcriptional 水平工作。最近，功能由 HSV-1 ICP27 蛋白质执行了的许多小说被显示出，包括 leptomycin B 抵抗，类型的抑制我干扰素发信号，病毒的信使 rna 翻译的规定并且决定 HSV-1 virions 的作文。

英文摘要：

The herpes simplex virus type 1 （HSV-1） infected-cell protein 27 （ICP27） is an essential, highly conserved protein involved in various steps of HSV-1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts. Recently, many novel functions performed by the HSV- 1 ICP27 protein were shown, including leptomycin B resistance, inhibition of the type I interferon signaling, regulation of the viral mRNA translation and determining the composition of HSV-1 virions