中文摘要：

目的：研究跌打止痛巴布剂体外经皮渗透吸收特征。方法：以Franz扩散池和离体裸鼠皮肤进行体外渗透试验，采用高效液相色谱法法同时测定蛇床子素和水杨酸甲酯的累积透皮量。结果：两种成分的体外经皮渗透均符合零级动力学方程，蛇床子素和水杨酸甲酯在15h内的透过率分别为13．50％和49．62％。二者在皮肤的蓄积量分别为17．56％和23．23％。结论：跌打止痛巴布剂中的有效成分在皮肤内有较强的蓄积作用，在15h内药物持续恒速释放，为控释长效和局部作用的制剂。

英文摘要：

OBJECTIVE To study the transdermal characteristics in vitro of Diedazhitong pathes. METHODS The permeation of the patches was studied with Franz diffusing cell and hareless mice skin. The cumulative percent releasing amount of osthol and methyl salieylate was determined by HPLC. RESULTS The releasing amount permeated of the two ingriedents in vitro became more numerous as time went on, which followed the zero releasing equation. The total amount permeated of osthol and methyl salicylate were 13.50% and 49. 62% respectively. The deposition of the two ingredients in mice skin were 17. 56% and 23.23%. CONCLUSION The effective ingriedents of Diedazhidong cataplasm have great deposition in skin and release at constant rate in 15 h, the patch is acontrolled, release and topical therapeutic preparation.