中文摘要：

就磁性的回声成像(MRI ) 在下面的发展而言超离频磁场(> 3 T ) ，新奇对比代理人(CA ) 为的探索超离频地 MRI 着急地被需要。此处，我们报导 polyethyleneimine (PEI ) 涂的 TbF ₃ nanoparticles (NP ) 它被一个灵巧的 solvothermal 方法综合，，潜在的双模式的 CA 为超离频地 MRI 和 X 光检查计算了断层摄影术(CT ) 。由于他们的强壮的常磁性， TbF ₃ NP 显示出优秀横向的 relaxivity (395.77 公里 ^-1????????????????????? 畳 ?? 猯扵崾猼灵 ?? 畳吗？？

英文摘要：

Considering the development of magnetic resonance imaging （MRI） under ultrahigh magnetic field （〉3 T）, the exploration of novel contrast agents （CAs） for ultrahigh field MRI is urgently needed. Herein, we report polyethyleneimine （PEI）-coated TbF3 nanoparticles （NPs）, which were synthesized by a facile solvothermal method, as potential dual-mode CAs for ultrahigh field MRI and X-ray computed tomography （CT）. Owing to their strong paramagnetism, the TbF3 NPs showed excellent transverse relaxivity （395.77 mM-l.s-1） and negligible longitudinal relaxivity under an ultrahigh magnetic field （7 T） with a great potential as a T2-weighted MRI contrast agent. Furthermore, by comparison with the clinically used CT CAs （iohexol）, the TbF3 NPs showed superior X-ray attenuation ability. The practical application for T2-weighted MRI and CT imaging was demonstrated with an animal model. Moreover, cell cytotoxicity and in vivo toxicity assessments implied the low toxicity of TbF3 NPs. In summary the above results indicate that TbF3 NPs are promising candidates for ultrahigh field MRI and CT dual-mode imaging.