中文摘要：

肿瘤热疗是一种极具应用前景的治疗模式。纳米医学的崛起极大拓展了肿瘤热疗应用的广度和深度,并赋予热疗新的功能。热敏纳米材料能够吸收外界能量并将其转化为热能。它可以将热量集中在肿瘤靶区内,进而减少热量对周围正常组织的损伤。热敏纳米材料还可以通过装载抗肿瘤药物、偶联或包裹具备成像功能的介质搭建诊疗一体化纳米平台。纳米材料介导的肿瘤热疗已取得突破性进展,本文对不同热敏纳米材料的抗肿瘤特性及其联合诊疗功能、纳米热疗目前存在的困难和挑战进行简要概述。

英文摘要：

Tumor hyperthermia has been recognized as a promising treatment modality. Quick development of nanotechnology in recent years has greatly broadened the application area of hyperthermia and endowed it with attractive new functions. Thermal sensitive nanostructures can absorb energy from the external source, and they can keep the therapeutic heating in the targeted region without damage to surrounding normal tissues. It can also be loaded with therapeutic drugs and/or functionalized with imaging properties to construct multifunctional theranostic nanoplatforms. Significant breakthroughs have been achieved in this new field recently. In this review, we will present an overview of different nanostructures mediated tumor hyperthermia in terms of different external stimuli sources, mainly focusing on the recent advances in this field. Different kinds of recently reported thermal sensitizer, imaging guidance modality, or combined therapies will be briefly elucidated, and the persisting challenges in current nanostructures mediated hyperthermia will also be discussed.