中文摘要：

目的研究选择性5-羟色胺再摄取抑制剂（SSRIs）帕罗西汀对SD大鼠睡眠呼吸暂停的影响。方法30只成年雄性SD大鼠随机分为帕罗西汀治疗组及对照组，每组15只，分别给予腹腔注射帕罗西汀（10mg·kg^-1·d^-1）及灭菌蒸馏水（2mL·kg^-1·d^-1）共7d。给药前后分别进行睡眠监测，观察睡眠呼吸暂停指数（AI）及睡眠结构的变化。结果帕罗西汀治疗组AI由（12．4±3．7）次／h降至（7．4±2．2）次／h（P=0．000），非快动眼睡眠（NREM）期叹息后呼吸暂停指数（PSAI）及自发呼吸暂停指数（SPAI）均有显著性下降（P=0．000，0．021），快动眼睡眠（REM）期呼吸暂停指数的下降无统计学意义。给予帕罗西汀后REM睡眠由8．6％降至8．0％（P=0．013），入睡潜伏时间由（20．7±9．1）min增至（30．0±15．7）min（P=0．038），REM潜伏期时间由（54．1±48．4）min增至（110．9±43．4）min（P=0．001）。对照组上述指标的变化均无统计学意义（P均〉0．05）。结论帕罗西汀可改善SD大鼠的睡眠呼吸暂停指数（AI）及NREM期PSAI和SPAI，对睡眠结构的影响表现为抑制REM睡眠并延长入睡潜伏期。

英文摘要：

Objective To evaluate the effects of selective serotonin reuptake inhibitors （SSRIs） on sleep apneas in Sprague-Dawley （SD） rats. Methods Thirty adult male SD rats were randomly divided into two groups （ 15 rats in each group）. The treatment group and the control group were injected intraperitoneally with paroxetine （10 mg·kg^-1·d^-1） and sterile distilled water （2 mL· kg^-1· d^-1） for 7 days respectively. Parameters about sleep apnea and sleep structure were measured before and after the treatment. Results In the treatment group, there was a significant reduction of apnea index （AI） from （ 12.4 ± 3.7 ） times/hour to （7.4 ± 2.2） times/hour （ P = 0. 000 ）. Both post sigh apnea index （ PSAI ） and spontaneous apnea index （SPAI） were decreased significantly （P =0. 000 and 0. 021 respectively） in non-rapid eye movement （NREM） sleep, but not in REM sleep. REM sleep was reduced from 8.6% to 8.0% （ P = 0. 013） and its latency was increased from （54.1 ± 48.4） min to （ 110.9 ± 43.4） min （ P = 0. 001 ） in the treatment group, as well as the sleep-onset latency [ from （ 20. 7 ± 9. 1 ） min to （ 30.0 ± 15.7 ） min, P = 0. 038 ]. Conclusion Paroxetine can reduce sleep apneas in SD rats during NREM sleep. Its effects on sleep structure include reducing REM time, increasing REM latency and sleep-onset latency.