中文摘要：

在这篇论文，我们报导 synaptotagmin 的 C2 领域我(猪圈我) 能把血浆膜的椽子与类脂化合物联系。我们表明那 phosphatidylinositol 4,5-bisphosphate (在目标膜和 Ca ²⁺ 的果仁 ₂) 是关键因素提高 C2 领域的木排协会。我们也发现 C2 领域的木排协会能被 C2A 或 C2B 独自完成，建议他们的木排协会可能是补足的。最后，我们显示破坏类脂化合物椽子或堵住猪圈我木排协会能显著地减少 Ca ²⁺-driven 版本充斥使挫折。我们的数据显示 C2 域的木排协会可能在调整 exocytosis 起一个重要作用。

英文摘要：

In this paper we report that the C2 domain of synaptotagmin I （syt I） could associate with lipid rafts of plasma membrane. We demonstrate that phosphatidylinositol 4,5-bisphosphate （PIP2） in the target membrane and Ca^2＋ are the key factors to enhance the raft association of the C2 domain. We also found that the raft association of the C2 domain could be fulfilled by either C2A or C2B alone, suggesting that their raft association might be complementary. Finally, we indicate that destroying lipid rafts or blocking syt I-raft association could significantly reduce the Ca^2＋-driven release of glutamates. Our data indicate that the raft association of the C2 domain might play an important role in the regulated exocytosis.