中文摘要：

WNT5A与胚胎发育以及肿瘤发生、侵袭、转移及化疗耐药等有重要关系.不同肿瘤中独特的WNT5A信号形成依赖于多种变量,包括受体、下游靶向效应分子、抑制分子以及来自于肿瘤微环境和肿瘤细胞外基质的外部影响.目前有研究对WNT5A作为肿瘤抑制因子还是肿瘤刺激因子的本质角色仍有争议,但WNT5A介导的信号转导通路与肿瘤的多种行为确有密切关系.

英文摘要：

WNT5A is associated with embryonic development and the development, invasion, metastasis and chemoresistance of tumor cells. The WNT5A signal in different tumors is specifically mediated by a number of factors, including receptors, downstream targets, inhibitors and external influences from tumor microenvironment and extracellular matrix. Eventhough it is still under debate whether WNT5A functions as a tumor suppressor or a promoter, WNT5A signal transduction pathway is closely associated with various tumor behaviors.