采用色谱技术对Fusarium solani 387#的次级代谢产物进行分离纯化,根据化合物的理化性质、波谱数据以及与文献谱图、数据对照的方法确定化合物的结构。从南海红树林内生真菌Fusarium solani 387#的次级代谢产物中分离得到了9个镰红菌素类化合物,分别鉴定为5(R)-deoxyfusarubin(1)、5(S)-deoxyfusarubin(2)、3-methyl ether fusarubin(3)、Fusarubin(4)、Anhydrofusarabin(5)、Anhydro-5-deoxyfusarubin(6)、2-acetonyl-3-methyl-7-methoxy-naphthazarin(7)、Javanicin(8)、2-acetonyl-3-methyl-5-hydrogen-7-methoxy-naphthazarin(9)。通过X-射线单晶衍射首次确定了化合物1和2的绝对构型及存在形式。
The secondary metabolites of Fusarium solani 387#from the South China Sea were studied.The structures of compounds were analyzed based on physical and chemical properties,and in comparison with the spectroscopic data with literatures published. Nine Fusarbin compounds were isolated from the mangrove endophytic fungus Fusarium solani 387#from the South China Sea,and their structures were identified as 5( R)-deoxyfusarubin( 1),5( S)-deoxyfusarubin( 2),3-methyl ether fusarubin( 3),Fusarubin( 4),Anhydrofusarabin( 5),Anhydro-5-deoxyfusarubin( 6),2-acetonyl-3-methyl-7-methoxy-naphthazarin( 7),Javanicin( 8) and 2-acetonyl-3-methyl-5- hydrogen-7-methoxy-naphthazarin( 9). The absolute configurations as well as the existing form of compound 1 and 2 were determined by the X-ray crystallography for the first time.