中文摘要：

外面屏蔽血壅滞症候群(BSS ) 的目的联系了 microRNA 并且因此为治疗高血压决定可能的目标。一个高精力的定序方法和数字基因表示定序理论被采用定序 microRNA (miRNA ) 和送信人 RNA (mRNA ) ，并且在人的脐的静脉 endothelial 房间决定微分表示的方法从高血压病人与浆液样品孵化了与或没有 BSS，和健康控制。结果是用基因预言软件的 confifirmed。13 miRNAs 和 11 mRNAs 全部的结果 A 分别地在 BSS/normal 组和 BSS/non-BSS 组两个都显示出统计差别。四目标 mRNA/miRNA 是 identifified：FRMD4A/hsa-miR-34a， MAP3K14/hsa-miR-34a， PER1/hsa-miR-34a，和 FGF2/hsa-miR-132。上面提及的结论四 mRNA/miRNA 对似乎与 BSS 涉及高血压的致病和维护。

英文摘要：

Objective： To screen out blood-stasis syndrome （BSS）-associated microRNA and therefore determine the possible target for treating hypertension. Methods： A high-energy sequencing method and digital gene expression sequencing theory were adopted to sequence microRNA （miRNA） and messenger RNA （mRNA）, and to determine differential expression in human umbilical vein endothelial cells incubated with serum samples from hypertension patients with or without BSS, and healthy controls. The results were confirmed using gene prediction software. Results： A total of 13 miRNAs and 11 mRNAs showed statistical difference both in the BSS/normal groups and BSS/non-BSS groups, respectively. Four pairs of target mRNNmiRNA were identified： FRMD4Nhsa-miR-34a, MAP3K14/hsa-miR-34a, PER1/hsa-miR-34a, and FGF2/hsa-miR-132. Conclusion： Four mRNNmiRNA pairs mentioned above seem to be involved in pathogenesis and maintenance of hypertension with BSS.