中文摘要：

核转录因子-κB（NF-κB）是一种广泛存在于体内多种细胞的核转录因子。静息状态下,NF-κB二聚体与其抑制蛋白IκB结合而存在于胞质中。当细胞受到外界刺激时,IκB磷酸化,使NF-κB活化进入细胞核,调节相应靶细胞的表达。本文对NF-κB家族、分子生物学特性及其在口腔疾病中发生和治疗中分子机制进行探讨,为口腔疾病致病机理以及探寻其＂干预治疗＂的关键靶点提供理论依据和新思路。

英文摘要：

Nuclear factor - κ B（ NF-κB） is a wide variety of cells in the body of nuclear transcription factor. In the resting state, NF-κB dimer bound with its inhibitory protein IκB and exists in the cytoplasm. When the cells stimulated by external, IκB can be phosphorylated, making NF-κB activation and entering the nucleus, then regulating the expression of the corresponding target cells. This paper on family of NF-κB, Molecular biological characteristics、and to explore its place in the oral diseases and treatment of the molecular mechanisms, pathogenesis of oral disease, to explore its key targets of therapeutic intervention provide for a theoretical basis and new ideas.