中文摘要：

目的探讨新疆汉族人群HLA-DRB1位点基因多态性与鼻咽癌（nasopharyngeal carcinoma,NPC）遗传易感性的关系。方法应用聚合酶链反应/序列特异性引物（PCR-SSP）方法对50例鼻咽癌患者（NPC组）及43例正常体检者（对照组）进行HLA-DRB1位点基因分型,比较两组HLA-DRB1位点等位基因频率分布差异。结果 NPC组DRB1＊1201较对照组降低（χ^26.785,P=0.009,OR=0.319,CI=0.131～0.777）,P值经Bonferroni校正后HLA-DRB1位点等位基因频率差异均无统计学意义（Pc〉0.05）。结论新疆汉族人群HLA-DRB1位点基因多态性与鼻咽癌遗传易感性无相关性。

英文摘要：

Objective To investigate whether the polymorphisms of HLA-DRBI alleles were associated with nasopharyngeal carcinoma （NPC）. Methods q50 NPC patients（NPC group）and 43 normal controls （con-trol group） of local Han people in Xinjiang were genotyped for HLA-DRB1 by PCR/SSP technique. Results The frequencies of HLA class 11 gene DRB1 ＊ 1201 were lower in NPC group than those in controls, no significance differences were observed between the two groups in HLA-DRB1 loci after Bonferroni correc-tion （Pc 〉0.05）. Conclusion The results could not prove that there was significant correlation between NPC and HLA-DRB1 locus in Xinjiang han population.