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中文摘要：
引言自从A．M．Sun发明了海藻酸钠-聚赖氨酸-海藻酸钠（APA）生物微胶囊（简称微胶囊）以来，微胶囊技术广泛用于动物细胞培养、细胞和酶的固定化、生化药物控释及基因运载等生物医学领域^[1-2]。目前，基于海藻酸钠的微胶囊制备工艺主要有乳化技术和液滴生成技术，前者生产规模易于扩大，但制备的微胶囊粒径分布较宽，
英文摘要：
In this paper, calcium alginate gel beads were prepared through a homemade microcapsule preparation system with multi-nozzles under forced high-voltage electrostatic field. The effect of operation parameters on the large-scale preparation of gel beads was analyzed. The results showed that the air pressure of feed was the decisive factor affecting the size and yield of gel beads, and the size distribution was dependent on several factors including the distribution of electric field, pulse potential, air pressure of feed, pulse frequency, pulse width and threshold potential. The gel beads with good sphericity, smooth surface and low dispersivity （CV 〈20%） can be prepared by adjusting and optimizing above parameters. It is more important that the yield of gel beads by the microcapsule preparation system is 20-40 folds higher than the traditional electrostatic droplet generator, which makes it possible to realize the large-scale preparation of gel beads.
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