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中文摘要：
针对当前大规模细胞培养过程优化和强化改进的难题，抓住细胞与环境因素相互作用存在的关键工程科学问题。以红豆杉细胞、酵母和转基因中国仓鼠卵巢癌细胞（CHO）和物理、化学、生物特定环境相互作用分别为植物细胞、微生物和动物细胞模型，运用化学工程具有的处理复杂问题、定量化、系统思想的优势和研究方法，对特定环境因素（包括物理、化学、生物微环境）与细胞相互作用的细胞生理特性与生产特性及其基本规律进行系统研究；获得环境因素如剪切力、生物诱导子与非生物诱导子、生产抑制因子和固定化微环境等影响下细胞生理和生产特性的变化的根本原因，从整体水平上系统地定量地阐释细胞对环境的响应机理以及群体细胞间的信号转导机制及相互作用规律，全面的解释环境对细胞生理特性和生产特性的影响，进而指导对细胞生产的改进。基于系统定量分析所获得的知识，利用基因电路原理设计对细胞进行分子水平的系统改造，为细胞培养过程的优化和强化开辟新策略。
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期刊论文
Spatial-temporal distribution of nitric oxide involved in regulation of phenylalanine ammonialyase a
Lipidomic analysis reveals activation of phospholipid signaling in mechanotransduction of Taxus cusp
Comparative Proteomic Analysis of Tolerance and Adaptation of Ethanologenic Saccharomyces cerevisiae
Cerium elicitor-induced phosphatidic acid triggers apoptotic signaling development in Taxus cuspidat
Dynamic lipidomic insights into the adaptive responses of Saccharomyces cerevisiae to the repeated v
Genome-wide transcriptional analysis of Saccharomyces cerevisiae during industrial bioethanol fermen
Inoculum size-dependent interactive regulation of metabolism and stress response of Saccharomyces ce
Expression of arabinogalactan proteins involved in Taxol production by immobilized Taxus cuspidata c
Analysis of phospholipids, sterols, and fatty acids in Taxus chinensis var. mairei cells in response
Responses of Taxus cuspidata to hydrodynamics in bubble column bioreactors with different sparging n
Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for imp
Effect of surface morphology and charge on the amount and conformation of fibrinogen adsorbed onto a
Chitosan-g-MPEG-Modified Alginate/Chitosan Hydrogel Microcapsules: A Quantitative Study of the Effec
Lipidome profiling of Saccharomyces cerevisiae reveals pitching rate-dependent fermentative performa
Metabolome profiling reveals adaptive evolution of Saccharomyces cerevisiae during repeated vacuum f
Metabolic profiling as a tool for understanding defense response of Taxus Cuspidata cells to shear s
Temporal quantitative proteomics of Saccharomyces cerevisiae in response to a nonlethal concentratio
Comparison of the secondary metabolites in Penicillium chrysogenum between pilot and industrial peni
Integrative investigation of lipidome and signal pathways in human endothelial cells under oxidative
Effect of surface wettability and charge on protein adsorption onto implantable alginate-chitosan-al
Microcapsules Embedded with Three-Dimensional Fibrous Scaffolds for Cell Culture and Tissue Engineer
In vitro and in vivo characterization of alginate/chitosan/alginate artificial cell microcapsules fo
Permeability changes of the cell-contained microcapsules visualized by confocal laser scanning micro
Microencapsulated umbilical cord blood cells repair mouse hepatic injury by intraperitoneal transpla
Comparative metabolic profiling of parental and inhibitors-tolerant yeasts during lignocellulosic et
Comparative lipidomic analysis of Cephalosporium acremonium insights into industrial and pilot ferme
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