中文摘要：

目的：考察丹参水溶性成分-丹参素和丹酚酸B的肠吸收特性。方法：采用大鼠在体单向肠灌流法,测定不同质量浓度丹参素和丹酚酸B在不同肠段、不同浓度的吸收分数（Fa,%）和表观渗透系数（Papp）。结果：丹参素和丹酚酸B在各肠段的吸收均比较差,十二指肠和空肠吸收较回肠和结肠略好,质量浓度、肠段对Fa和Papp无明显影响。结论：丹参素和丹酚酸B在全肠道以被动扩散方式吸收,且吸收比较差,无特定吸收部位,不受药物浓度的影响。

英文摘要：

Objective：To study the absorption of salvianolic acid B and danshensu.Method：In situ single pass perfusion model was used and the concentration of salvianolic acid B and danshensu in perfusate were determined by HPLC in combination with ultraviolet detector.Result：The apparent penetration coefficient（Papp） and absorption percentage（Fa） of danshensu and salvianolic acid B were all low at different concentration in four different regions of intestine of rat（duodenum,jejunum,ileum,colon）.The absorption rate of dashensu was faster than salvianolic acid B in this study.The values of the Fa a and the Papp were not significantly affected by concentration of perfusion solution and intestinal segments.Conclusion：The intestine absorption characteristics of salvianolic acid B and danhensu was poor at all segments of intestine in rats where there is no special ab sorption site and showed the passive diffusion process.