中文摘要：

<正>丝裂原活化蛋白激酶(mitogen-activated proteinkinases,MAPKs)信号转导通路是细胞外信号引起细胞核内反应的重要通路,而细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)通路是MAPKs家族中的重要成员,其异常活化与类风湿关节炎(rheumatoid arthritis,RA)关节破坏的病理过程密切相关。

英文摘要：

The excessive activation of extracellular signal -regulated kinase （ERK） signaling pathway, which is a significant feature of rheumatoid arthritic（RA） arthropathy, plays an important role in the process of synoviocyte dysfunction and destruction of cartilage and bone. Understanding the pathomechanism of ERK signaling in RA provides a new target for developing new drug and therapeutic strategy. This review summarizes the current knowledge of the activation, regulation and function of ERK pathway, and also analyzes the role of this signaling transduction in the destruction of joints and the pathogenesis of RA.