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中文摘要：
为研究抗血管生成因子angiostatin和抗血管生成药物endostatin对肿瘤血管生成和肿瘤细胞的抑制作用，建立耦合肿瘤血管生长、肿瘤生长和血液灌注的数学模型．模拟结果显示抗血管生成因子angiostatin和抗血管生成药物endostatin可明显抑制血管生成和减少肿瘤细胞数量，从而起到改善肿瘤组织内部异常微环境的作用．模型可作为肿瘤抗血管生成治疗的一种理论研究．
英文摘要：
To investigate the inhibiting effects of anti-angiogenic factor angiostatin and anti-an- giogenic drug endostatin on tumour angiogenesis and tumour cells, a coupled mathematical model of tumor angiogenesis with tumour growth and blood perfusion was developed. The sim- ulation results showed that angiostatin and endostatin could improve the abnormal microenvi- ronment inside the tumour tissue, by effectively inhibiting the process of tumor angiogenesis and decreasing the number of tumour cells. The present model can be used as a valid theoretical method in the investigation of tumour anti-angiogenic therapy.
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