中文摘要：

目的应用静息态功能磁共振局部一致性方法研究儿童全身强直发作性癫痫患者脑区异常活动,探讨其发生的病理生理机制。方法对8例儿童全身强直发作性癫痫患者和30例正常儿童进行磁共振扫描,并计算全脑局部一致性的值,进行组间比较并研究局部一致性与病程的相关性。结果与对照组相比,癫痫组Re Ho值增高的脑区为大脑深部核团（扣带回,丘脑,楔前叶等）,运动相关脑区,额下回,枕叶,颞叶和小脑;Re Ho值降低的脑区为双侧额中回、右侧颞中回、左侧颞上回、双侧中央后回、左侧舌回。全身强直发作性癫痫与病程呈正相关的脑区为左侧楔前叶、左侧顶上小叶、右侧中央前回、右侧中央后回;与病程呈负相关的脑区为右侧楔前叶、右侧角回、中央旁小叶。结论局部一致性分析方法可以有效地反映癫痫患者异常的神经功能变化,有助于发现强直发作性癫痫发生的病理生理机制。

英文摘要：

Objective Regional homogeneity（ReHo） method of resting state functional MRI was applied to study abnormal brain activity of childhood generalized tonic seizures,and detect pathophysiological mechanisms of it. Methods Resting state fMRI scanning were performed to 8 patients with childhood generalized tonic seizures and 30 healthy children.The MRI data were compared and analyzed by using ReHo analysis method, the ReHo value were calculated between two groups and the correlation were studied between the ReHo value and seizure duration. Result Compared with control group, the brain regions of increased ReHo value in experimental group are located in deep brain nuclei（cingulate gyms, precuneus, thalamus, et al.）, motor related brain region, inferior frontal gyms, occipital lobe, temporal gyms, cerebellum; the brain regions of decreased ReHo value in experimental group are bilateral middle frontal gyms, right middle temporal gyms, left superior temporal gyms, bilateral posterior central gyms, lingual gyms.The positive correlation between ReHo and epilepsy duration was found in the following brain regions： left precuneus, left superior parietal lobe, right precentral lobule, right postcentral lobule.At the same time negative correlation was found in the right precuneus, right angular gyms, paracentral lobule. Conclusion ReHo analytical method can effectively reflect abnormal neurological functional change of the epilepsy patients, and help to investigate and explain the pathophysiology of idiopathic generalized tonic seizures.