中文摘要：

目的探讨单节段斜外侧椎间融合术（oblique lateral interboy fusion，OLIF）治疗腰椎退行性疾患的临床应用价值。方法收集2014年10月至2016年5月在我院36例应用单节段OLIF术联合或不联合后路椎弓根钉棒内固定治疗下腰椎病变的患者资料，其中男11例，女25例；年龄32-75岁，平均（55．2±13．6）岁。椎间盘源性腰痛15例，腰椎轻度滑脱伴或不伴节段性不稳定21例；手术节段L4/5，30例，L3/4 6例。所有患者于术前、术后第1天、术后3d检查生化全套测定肌酸激酶水平；临床结果采用视觉模拟疼痛评分（visual analoguescale，VAS）和Oswestry功能障碍指数（Oswestry disability in-dex，ODI）评估；摄腰椎正侧位x线并评估内植物及椎间融合情况。结果本组36例中25例联合后路椎弓根钉棒内固定，36例的手术时间为46-175min，平均（112±43）min；其中OLIF术手术时间46-89min，平均（57±23）rain。术中出血量30-180ml，平均（63±35）ml。术后住院日3-7d，平均（4．5±2．1）d。术前平均肌酸激酶水平为（63．5±16．8）IU／L，术后第1天（416．8±152．1）IU／L，术后3d（112．4±37．5）IU／L。所有患者术后VAS和ODI评分均显著降低，VAS评分由术前的（8．3±2．3）分降至术后6月的（1．6±0．4）分，ODI评分由术前的（69．2±17．5）分降至术后6月的（10．7±2．7）分。总体并发症发生率为25％（9／36），其中术中并发症为8．3％（3／36，均为融合器沉降），术后并发症为16．7％（6／36），包括1例术侧腰大肌无力，1例术侧大腿前侧疼痛，1例对侧屈髋疼痛，1例术侧交感链损伤症状，2例取髂骨区疼痛。所有并发症在随访过程中均得到不同程度缓解或消失。结论OLIF作为一种脊柱外科新技术，可获得良好的短期疗效，具有临床应用价值，但是其远期的随访结果有待进一步观察、总结。

英文摘要：

Objective To evaluate the clinical outcomes of one-level oblique lateral interbody fusion （OLIF） for the treat- ment of degenerative lumbar diseases. Methods A total of 36 patients, 11 males and 25 females with ages from 32 to 75 （average 55.2 ± 13.6 years）, underwent one-level OLIF with or without posterior pedicle screw-rod instrumentations from October 2014 to May 2016. The index diagnosis was discogenic back pain in 15 cases, and spondylolisthesis with or without segmental instability in 21 cases. The distribution of operative level was 30 cases at L4/5 and 6 cases at L3~4. The changes of serum level of creatinine ki- nase was measured 1 and 3 days post-operatively, and compared to that of the pre-operative one. Clinical outcomes were evaluated using visual analogue scale （VAS） and Oswestry disability questionnaire （ODI） scores. Lumbar X-ray was taken and the clinical outcomes were re-assessed. Results 25 in the 36 patients underwent supplementary posterior pedicle screw-rod instrumentation with OLIF procedures. The operation lasted for 46-175 min, with a mean duration of （112±43） mifi. Blood loss during the opera- tion was 30-180 ml, with a mean of （63 ± 35） ml. Average length of stay was （4.5±2.1） d, ranging from 3-7 d. Serum level of creati- nine kinase was （63.5±16.8） IU/L before operation, （416.8±152.1） IU/L 1 day after operation, （112.4±37.5） IU/L 3 days after opera- tion. The VAS and ODI score decreased from （8.3±2.3） pre-operatively to （1.6±0.4） 6 months post-operatively, and from （69.2± 17.5） to （10.7±2.7）, respectively. The total incidence of complications was 25%, including 8.3% of intra-operative complications （3 cases of cage subsidence） and 16.7 % of post-operative ones. The latter consisted of ipsilateral hip flexor weakness in 1, ipsilateral anterior thigh pain in 1, contralateral pain in flexion of hip in 1, ipsilateral sympathetic chain injury in 1, and pain in area of iliacbone donor site in 2. All symptoms were released