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肾动态显像评价和预测活体供肾者肾功能
  • ISSN号:1003-3289
  • 期刊名称:《中国医学影像技术》
  • 时间:0
  • 分类:R817.4[医药卫生—影像医学与核医学;医药卫生—放射医学;医药卫生—临床医学] R814.42[医药卫生—影像医学与核医学;医药卫生—放射医学;医药卫生—临床医学]
  • 作者机构:[1]北京大学第一医院核医学科,北京100034, [2]北京大学第一医院泌尿外科,北京100034
  • 相关基金:[基金项目]国家重点基础研究发展计划基金973计划(2006CB705705)、国家自然科学基金(30470498,30670583)、北京大学985Ⅱ期基金(985-2-056).
中文摘要:

目的分析肾动态显像在评价活体供肾者肾功能状况以及预测术后保留肾功能中的价值。方法36例供肾者术前均接受^99Tc—DTPA肾动态显像,计算出总肾和分肾GFR值(d—GFR)。供者于术前、术后3d、10d测定血清肌酐水平,利用简化MDRD方程计算GFR值(e-GFR);利用肾动态显像测得的分肾摄取率计算保留肾的术前e-GFR。将供者按不同指标分组,分别对各组间保留肾的术前、术后3d、10d的e-GFR值进行统计学分析。结果术前保留肾d-GFR值为(49.4±11.7)ml/min,e-GFR值为(54.7±8.7)ml/min。老年组术前保留肾、术后3d的e-GFR值显著低于中青年组;男性组术后e-GFR值和术后10d的e-GFR变化率均明显低于女性组;低d-GFR组术后3d、10d的e-GFR值显著低于高d-GFR组,差异有统计学意义;低e-GFR组和高e-GFR组两组间术后e-GFR的数值和变化率差异均无统计学意义。结论肾动态显像能够很好地评价活体供肾者的总肾和分肾功能,有助于预测供者术后肾功能的恢复情况。

英文摘要:

Objective To explore the value of renal dynamic imaging in evaluating and predicting renal function of living donors before and after the renal ectomy. Methods A total of 36 living donors underwent ^99mTc-DTPA renal dynamic imaging before operation, and the total and split GFR value (d-GFR) were obtained. Blood creatinine was measured before oper ation, 3 and 10 d after operation, then the GFR value (e-GFR) was calculated with simplified MDRD equation. The donors were divided into different groups according to different indexes, and the e-GFR values before operation, 3 and 10 d after operation were analyzed using independent sample t test. Results Before the operation, d-GFR of the remaining renal was (49.4±11.7)ml/min and e-GFR was (54.7±8.7)ml/min. The e-GFR of the remaining renal before operation and 10 d after operation in the elder group was lower than that in the young group. The e-GFR after operation and change rate of e-GFR 10 d after operation in male group were lower than those in female group. The e-GFR 3 and 10 d after operation in low d- GFR group were lower than those in high d GFR group, and change rate of e-GFR 3 and 10 d after operation were also lower in low d GFR group, but there was no difference of the value and change rate of e-GFR after operation between high e-GFR group and low e-GFR group. Conclusion Renal dynamic imaging is valuable to assess the total and split renal function of living donors, and contributes to predict renal function of the donors after operation.

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期刊信息
  • 《中国医学影像技术》
  • 北大核心期刊(2011版)
  • 主管单位:中国科学院
  • 主办单位:中国科学院声学研究所
  • 主编:李坤成 田家玮
  • 地址:北京市海淀区北四环西路21号大猷楼502室
  • 邮编:100190
  • 邮箱:cjmit@mail.ioa.ac.cn
  • 电话:010-82547901/2/3
  • 国际标准刊号:ISSN:1003-3289
  • 国内统一刊号:ISSN:11-1881/R
  • 邮发代号:82-509
  • 获奖情况:
  • 《CAJ-CD》规范执行优秀奖期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,波兰哥白尼索引,荷兰文摘与引文数据库,荷兰医学文摘,英国科学文摘数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:51887