中文摘要：

目的研究慢性砷暴露对雌性大鼠的内分泌干扰作用。方法 50只4周龄雌性Wistar大鼠随机分成对照组（饮用去离子水）及砷暴露组（饮用砷含量分别为0.05、0.1、0.2和0.4μg/ml水）,32周后采用放射免疫法测定血清雌二醇（E2）、孕酮（P）、黄体生成素（LH）、卵泡刺激素（FSH）、促性腺激素释放激素（GnRH）、垂体泌乳素（PRL）和皮质醇（Cort）含量。结果与对照组相比,各浓度砷暴露组E2和P含量均有升高趋势,LH水平有降低趋势,但差异均无显著性（P〉0.05）;FSH和PRL水平在低砷暴露组有升高趋势,而高砷暴露则有降低趋势（P〉0.05）;GnRH和Cort含量升高,且0.4μg/ml暴露组大鼠GnRH明显升高（P〈0.05）,0.1、0.4μg/ml组大鼠Cort升高明显（P〈0.05）。结论慢性砷暴露可干扰雌性大鼠体内上述激素的水平。

英文摘要：

Objective To study the effect on endocrine system of female rats exposed to chronic arsenic.Methods 50 female Wistar rats were randomly divided into five groups： control group,0.05,0.1,0.2 and 0.4μg/ml arsenic groups.The hormone levels were determined by RIA exposing arsenic for 32 weeks.Results The hormone levels of female rats were disorder in different arsenic groups.E2,P level increased and LH level decreased in arsenic groups compared to controls,but there were no significant differences（P 0.05）.FSH and PRL level increased in low arsenic group and decreased in high arsenic groups（P 0.05）.GnRH and Cort level increased in arsenic groups,and GnRH level obviously increased in 0.4μg/ml group and Cort level obviously increased in 0.1 and 0.4μg/ml groups（P 0.05）.Conclusions The hormone levels were disordered in rats exposed to chronic arsenic.