中文摘要：

Methoxyl poly (乙烯乙二醇)(mPEG -- 哦) 成功地 grafted 到到产量的分叉的 polyethyleneimine (hy-PEI ) 上水可溶的接枝共聚物 mPEG-g-PEI。这共聚物可以由 ligand 交换包装超级顺磁的氧化铁(SPIO ) 。在聚合物的 SPIO 重量百分比涂的 nanoparticles 决心是 55% ， nanoparticles 的尺寸和希腊语的第六个字母潜力分别地是 50 nm 和 12 mV。抗体固定到建筑群(mPEI-g-PEG-SPIO ) 上，表面层被激活的单个链完成对前列腺干细胞抗原(PSCA ) 的单音的同种细胞的抗体。我们的学习证明单身者锁住抗体 functionalized nanoprobe (痂 _{有一种小尺寸的 PSCA} -PEI-g-PEG-SPIO) 能明确地进入前列腺癌症房间，到 44.76% 的前列腺癌症房间的减少的 MRI T2 加权的信号紧张。我们的结果表明这个磁性的 nanoparticulate 系统的潜力为前列腺癌症(PCa ) 的早诊断作为新奇 MRI nanoprobe 答应了。

英文摘要：

Methoxyl poly （ethylene glycol） （mPEG-OH） was successfully grafted onto branched polyethyleneimine （hy-PEI） to yield a water soluble graft copolymer mPEG-g-PEI. This copolymer may package superparamagnetic iron oxide （SPIO） by ligand exchange. The SPIO weight percentage in the polymer coated nanoparticles was determined to be 55%, the size and zeta potential of nanoparticles was 50 nm and 12 mV respectively. Antibody fixation onto the complex （mPEI-g-PEG-SPIO） surface layer was achieved by activated single chain monoclonal antibody against prostate stem cell antigen （PSCA）. Our study showed that the single chain antibody functionalized nanoprobe （scAbpscA-PEI-g-PEG-SPIO） with a small size can specifically enter the prostate cancer cells, decreasing MRI T2-weighted signal intensity of prostate cancer cells to 44.76%, Our results revealed that the potential of this magnetic nanoparticulate system promised as a novel MRI nanoprobe for early diagnosis of prostate cancer （PCa）.