中文摘要：

近年来免疫学的发展日新月异，但与其他系统药物相比，免疫系统药物的发展十分落后。低选择性是现有免疫抑制剂的重要缺陷，这使得需要长期用药的自身免疫性疾病常因药物的严重副作用而使治疗无法持续。因此，免疫系统药物的研制必须另辟蹊径。本文在阐述免疫抑制剂发展现状的基础上，通过本课题组关于中药及其成分的研究结果，提出了选择性抑制活化T细胞的免疫抑制新模式，从作用特点、作用机理、代谢产物以及与现有免疫抑制剂的比较等角度论证了选择性免疫抑制的可行性，从而为免疫性疾病的治疗以及新型免疫抑制剂的研制提供新的思路。

英文摘要：

Despite the marked progress in immunology, the research and development of the remedies for immune diseases really dropped behind those for others. The broad-spectrum inhibition on various cells or tissues is the main problem existing in current immunosuppressive agents. Such low selectivity of the drug effect usually leads to the discontinuity of therapy for patients, who should receive long-term treatment. Thus, a new pathway is required for the discovery of remedies for immune diseases. This review summarizes some results on Chinese herbal drugs and their principles obtained in authors＇ laboratory after an overview of the current immunosuppressants for comparison. A novel regulation on immune response, selective inhibition of activated T lymphocytes, and its possible application as a selective immunosuppressive therapy are suggested.