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中文摘要：
在前一重点项目发现选择性免疫抑制模式、阐明相关化合物作用机理的基础上，确证选择性作用的分子靶标，阐明其功能，建立相应评价体系，为研制新型免疫抑制剂提供理论基础和候选药物储备。包括阐明Astilbin选择性调控活化T细胞的分子靶标-hnRNP A1及其与电压依赖性阴离子通道(VDAC)的相互作用；探讨T细胞激活与hnRNP A1线粒体定位的关系，阐明hnRNP A1调控VDAC开启的分子基础；建立以选择性调控VDAC为目标的药物评价体系在酵母上表达VDAC、在脂质体上构建人工VDAC、在活化T细胞上检测hnRNP A1及细胞色素C，考察各种药物或试剂的作用，为发现基于调控hnRNP A1-VDAC相互作用的药物打下基础；选取同样能选择性抑制活化T细胞的黄柏内酯和梣酮等化合物，探讨其诱导凋亡的途径及作用特点，通过与Astilbin比较，阐明VDAC调控体系对选择性免疫抑制药物发现的示范意义
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期刊论文
Astilbin inhibits the adhesion of T lymphocytes via decreasing TNF-α and its associated MMP-9 activi
An Anticancer Effect of Curcumin Mediated by Down-regulating PRL-3 Expression on Highly Metastatic M
Involvement of Na+, K+-ATPase and its inhibitors in lung epithelial inflammation by HuR-mediated cyt
Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatm
Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and in
Sorafenib induces apoptosis of HL60 cells through inhibiting Src kinase mediated STAT3 phosphorylati
Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling
Integrin a6high cell population functions as an initiator in tumorigenesis and relapse of human lipo
会议论文
Selective elimination of activated T cells via Fas ligand-dependent apoptosis by fraxinellone for th
Reciprocally regulating the roles of STAT1 and STAT3 in T cell-mediate hepatitis: the protective rol
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