中文摘要：

CXCR7作为G蛋白偶联受体超家族的一员，能与趋化因子CXCL11（I-TAC）及CXCL12（SDF—1）结合，具有功能性受体与诱骗受体的双重属性。CXCR7在与其配基结合后并不下传信号，但可以通过建立合适的趋化因子的梯度而促进肿瘤的生长与转移。本文主要介绍近年来有关CXCR7在肿瘤生长、转移中作用的研究进展。

英文摘要：

CXCR7, formerly called RDC1/CCX-CKR2, is a G-protein coupled receptor which with high affinity binds the CXCL11 （I-TAC） and CXCL12 （SDF-1）. This receptor may lead to an internalization of signals and will promote tumorigenesis, development and metastasis through binding to the ligand CXCL12. This review aimed to illustrate the recent advancement in the role of CXCR7 in tumorigenesis and metastasis.