中文摘要：

目的探讨成人外周血胆红素水平与高血压的关系。方法对江苏省苏南地区整群抽样的某乡镇社区2238人进行现场流行病学调查,分为高血压组和对照组进行病例对照研究。高血压组和对照组组间计量资料比较采用t检验,组间分类资料比较采用χ2检验,关联分析应用Logistic回归分析。结果高血压组的年龄、体质量指数（BMI）、血糖（Glu）、总胆固醇（TCH）和低密度脂蛋白胆固醇（LDL-C）均显著高于对照组（P〈0.05）,2组间的总胆红素（TBIL）、直接胆红素（DBIL）和间接胆红素（IDBIL）差异均无统计学意义（P〉0.05）;进一步按年龄进行分层分析,结果发现在〈55岁的年龄组中,DBIL与高血压患病风险升高存在显著关联（P〈0.05）,而在≥55岁人群中,TBIL和IDBIL均与高血压患病风险降低有关（P〈0.05）;进一步调整年龄、性别、BMI、TCH、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、LDL-C、Glu、吸烟与饮酒混杂因素后,在〈55岁年龄组,DBIL与高血压患病风险升高仍存在关联（P〈0.05）;总人群的舒张压（DBP）和DBIL呈正相关（P〈0.05）。结论 〈55岁的人群中胆红素水平升高与高血压患病风险增加存在关联,而在≥55岁年龄组胆红素水平升高可能具有一定保护作用,结果仍需进一步研究加以证实。

英文摘要：

Objective To investigate the relationship between peripheral blood bilirubin（ BIL）variation and hypertension in the elderly. Methods By stratified cluster sampling,an epidemiological survey was carried out in southern Jiangsu involving 2238 individuals in total,and the case group and control group consisted of 1164 hypertensive individuals and 1074 individuals without hypertension respectively. The analysis of variance was adopted to compare the quantitative data between the two groups,and chi-squared tests were adopted to compare qualitative data. Logistic regression analysis was used to analyze the correlation. Results In the case group,hypertension,age,and the levels of body mass index,blood glucose,total cholesterol and low-density lipoprotein cholesterol were significantly higher than those in the control group（ P〈0. 05）. No significant difference in total bilirubin（ TBIL）,direct bilirubin（ DBIL） and indirect bilirubin（ IDBIL） was observed between case group and control group（ P〉0. 05）. Further stratification analysis showed that in the 〈55-year group,the level of DBIL was positively associated with hypertension（ P〈0. 05）,while in ≥ 55-year group,TBIL and IDBIL were negatively associated with hypertension（ P〈0. 05）. After adjustment for confounding factor including age,gender,body mass indexs,total cholesterol,triglyceride,high-density lipoprotein cholesterol,lowdensity lipoprotein cholesterol,fasting glucose,smoking and drinking,the association of DBIL with hypertension persisted in the 55-year group（ P〈0. 05）. In whole study population,DBIL and diastolic blood pressure were positively correlated（ P〈0. 05）. Conclusions The finding of this study indicates that increases bilirubin levels are significantly associated with the prevalence risk of hypertension 〈55 years old population while in≥55 ages old population the increased bilirubin may have a protective effect on hypertension and further studies would be warranted.