中文摘要：

目的：研究参与AGER氧化损伤通路的高迁移率族蛋白1（HMGBI）基因的遗传变异对于高血压药物效果的影响。方法：采用流行病学现况调查方法，对服用复方利血平、珍菊降压片和降压片的高血压患者（780例）进行流行病学和临床生化指标资料的收集。位点选择采用连锁不平衡分析和生物信息学的功能预测相结合的方法，选择HMGBl基因的3个标签单核苷酸多态性（tagSNPs）与服用不同降压药物后人群血压水平的关系。结果：服用复方利血平的高血压病人中，rs1412125位点与舒张压水平呈线性负相关，携带CC等位基因的病人舒张压水平明显低于TT和TC等位基因，调整混杂因素后P值为0．040。服用珍菊降压片的女性高血压病人中，rs1045411的G到A的突变和rs2249825的C到G的突变，收缩压都有明显的下降，校正混杂因素后P值分别为0．044、0．043。服用降压片的≥55岁人群中，rs2249825位点不同基因型之间的收缩压的差异，校正协变量后仍有统计学意义（P=0．048）。结论：HMGBI基因多态性可能影响复方利血平、珍菊降压片和降压片的降压效果。

英文摘要：

AIM： To explore the effect of HMGBI gene polymorphism on drug treatment in patient with essential hypertension, to raise cure rate of hypertension patients by reasonable cure. METHODS： A cross-sectional study of 780 patients with hypertension that were recruited by taking compound reserpine, Zhen Ju Jiang Ya Tablet and Jiang Ya Tablet, was conducted and three tagging single nucleotide polymorphisms （ tagSNPs ） of HMGB1 gene （ rs1045411, rs1412125, rs2249825） were selected by linkage disequilibrium （LD） analysis and functional pre- diction. A quantitative trait analysis was per- formed for evaluating the relation between HMGBI genetic variation and blood pressure by taking different antihypertensives drugs. RE- SULTS： In hypertensive taking compound reser- pine, after adjusting the confounding factors, diastolic blood pressure （DBP） linearly de-creased with the variation （T〉C） of rs1412125 （P=0. 040）. In female hypertensive taking Zhen Ju Jiang Ya Tablet,after adjusting the covariant, systolic blood pressure （SBP） significantly de- creased with the variation（G〉A） of rs1045411 and the variation （C〉G） of rs2249825 respec- tively （P=0. 044 and 0. 043）. In age≥55 hyper- tensive taking Jiang Ya Tablet, different geno- types were significantly different after adjusting the covariant （ P = 0. 048）. CONCLUSION. HMGB1 gene might affect the antihypertensive effect of compound reserpine, Zhen Ju Jiang Ya Tablet and Jiang Ya Tablet.