中文摘要：

目的: 导致放射的大脑损害(RIBI ) 是头部的放射治疗(CRT ) 导致的最普通、严重的不利效果。在现在的学习，我们在老鼠在 RIBI 上检验了繁体中文药 Shenqi Fuzheng 注射(SFI ) 的效果，并且探索了内在的 mechanisms.Methods : C57BL/6J 老鼠受到 20-Gy CRT 的单个剂量。老鼠与 SFI 被对待(20 mL·； kg ^-1·d^-1, ip ) 为 4 个星期。莫利斯舞水迷宫测试被用来估计认知变化。Evans 蓝漏和山葵 peroxidase (HRP ) 试金被用来评估血大脑障碍(BBB ) 的正直。在大脑纸巾的煽动性的因素和 microglial 激活的表达式用 RT-PCR，西方的弄污和 immunofluorescence staining.Results 被检测: 引起的 CRT 在身体重量和鼠标的寿命标记减小，并且显著地损害了他们的空间学习。而且， CRT 显著地增加了 BBB 渗透，激活的 microglia 的数字， TNF-α 的表示层次；并且 IL-1β；，并且在大脑纸巾的 phosphorylated p65 和 PIDD-CC (有一个死亡领域的导致 p53 的蛋白质的两次劈开的碎片) 的层次。四星期的 SFI 处理(管理了因为 2 个星期在前和在 CRT 以后的 2 个星期) 显著地不仅改进了物理地位，幸存，并且在对待 CRT 的老鼠的空间学习，而且在大脑纸巾稀释了所有导致 CRT 的变化。四星期的 SFI 预告的处理(在 CRT 前为 4 管理了星期) 是更少的 effective.Conclusion : SFI 的管理有效地经由 NF-κ 的抑制稀释导致照耀的大脑损害； B 发信号小径和 microglial 激活。

英文摘要：

Aim： Radiation-induced brain injury （RIBI） is the most common and severe adverse effect induced by cranial radiation therapy （CRT）. In the present study, we examined the effects of the traditional Chinese medicine Shenqi Fuzheng Injection （SFI） on RIBI in mice, and explored the underlying mechanisms. Methods： C57BL/6J mice were subjected to a single dose of 20-Gy CRT. The mice were treated with SFI （20 mL·kg^-1-d^-1, ip） for 4 weeks. Morris water maze test was used to assess the cognitive changes. Evans blue leakage and a horseradish peroxidase （HRP） assay were used to evaluate the integrity of the blood-brain barrier （BBB）. The expression of inflammatory factors and microglial activation in brain tissues were detected using RT-PCR, Western blotting and immunofluorescence staining. Results： CRT caused marked reductions in the body weight and life span of the mice, and significantly impaired their spatial learning. Furthermore, CRT significantly increased the BBB permeability, number of activated microglia, expression levels of TNF-α and IL-1β, and the levels of phosphorylated p65 and PIDD-CC （the twice-cleaved fragment of p53-induced protein with a death domain） in the brain tissues. Four-week SFI treatment （administered for 2 weeks before and 2 weeks after CRT） not only significantly improved the physical status, survival, and spatial learning in CRT-treated mice, but also attenuated all the CRT-induced changes in the brain tissues. Four-week SFI pretreatment （administered for 4 weeks before CRT） was less effective. Conclusion： Administration of SFI effectively attenuates irradiation-induced brain injury via inhibition of the NF-κB signaling pathway and microglial activation.