中文摘要：

采用FLUENT软件模拟了T型引物梯度产生器中的细胞转动过程,分析了细胞转动的线速度、方向和细胞尺寸对其化学微环境的影响.结果表明：在细胞转动的过程中,由于产生额外的引物输运,使其周围引物浓度在一定时间内发生变化,但最终达到稳态;顺时针与逆时针转动的细胞对微环境的搅动效果相反;增加细胞转动的线速度,可以增强其对微环境的搅动效果,但将导致趋化偏转角增大而使得趋化动力减小;细胞尺寸对于细胞趋化偏转角的影响较小,但对其趋化动力的影响较大.

英文摘要：

The influence of cell rotation on its chemical microenvironment was investigated by performing systematic numerical simulations.The influences of the line speed,rotational direction and the cell size were investigated.The results show that when a till cell starts rotating,the ambient concentration field and the flow field keep changing until they reach steady states.Different cell rotational directions lead to dramatic changes on the disturbing effect;and the peripheral speed of the cell enhances the stirring effect and hence decreases the apparent chemotactic effect.This paper contributes to the development of chemotactic experimental platform and quantitative measurement methodology.