中文摘要：

吲哚胺2,3-二加氧酶（indoleamine2,3-dioxygenase,IDO）是催化色氨酸沿犬尿氨酸代谢途径分解的限速酶,已被证实与肿瘤、阿尔茨海默病、抑郁症和白内障等多种人类疾病的发病机制密切相关。IDO抑制剂是具有新药靶、新机制的广谱药物,应用前景非常广阔。

英文摘要：

Indoleamine 2,3-dioxygenase（IDO） is a monomeric 45 kDa heme-containing dioxygenase that catalyzes the initial and rate limiting step of L-tryptophan（L-Trp） catabolism along the kynurenine pathway（KP）.IDO has been confirmed to have the close relationship of the pathogenesis mechanism with cancer,Alzheimer＇s disease,depression,age-related cataract as well as other diseases characterized by pathological tryptophan metabolism.It is a broad-spectrum agent with the new molecular target and mechanism,which has the promising application prospects.