中文摘要：

目前发展疟疾疫苗仍然是防治和消灭疟疾感染的重要手段,红内期是疟原虫致病并引起临床症状的主要时期,发展有效的红内期疫苗不仅能减轻临床症状,还可降低血中配子体数量从而起到阻断传播作用。本文就目前红内期亚单位疫苗候选抗原及全虫疫苗的研究现状作一综述。

英文摘要：

A key tool for control and elimination of malaria is an effective vaccine.The pathology and clinical symptoms of malaria are associated with the blood stages of the parasite＇s life cycle.The development of blood stage vaccines can reduce or clear the clinical symptoms and reduce the transmission through the mosquito vector.The review focuses only on advantages and challenges of candidate antigens of blood-stage subunit vaccine and whole blood-stage parasites vaccine.