中文摘要：

目的：初步探讨中国北方汉族人群原发性胆汁性肝硬变（PBC）患者与人类白细胞抗原（HLA）-DRB等位基因的相关性。方法：利用基因芯片技术对40例中国北方汉族PBC患者和67例健康对照人群进行了HLA-DRB等位基因的分型检测。两组年龄构成和男、女比例均无统计学差异。结果：本组PBC患者中HLA-DR7的出现频率为50％，远高于健康对照组的10．4％（X^2=20．77，P=0．000，RR=8．57），同时也高于文献报道的两组中国北方健康人群中的出现频率[分别为23．2％（N=342，P=0．000）和29％（N=255，P=0．008）3。本组PBC患者中HLA-DR8的检出率为22．5％，明显高于健康对照组的7．5％（X^2=4．980，P=0．026，RR=3．60），同时也高于文献报道的两组中国北方健康人群中的出现频率[11．2％（N=342，P=0．038）和10．2％（N=255，P=0．025）]。结论：HLA—DR7和DR8基因可能与中国北方人群的PBC发病有一定的相关性，其中DR？在国外文献中尚未见报道。

英文摘要：

Objective： To investigate the relationship between HLA-DRB alleles and primary biliary cirrhosis （PBC） in patients living in northern China. Methods： The HLA-DR genes of 40 PBC patients and 67 healthy controls were genotyped by using DNA microarray technique. The subjects in the 2 groups were matchable in their ages and gender ratios. Results： The frequency of HLA-DR7 was 50% in PBC patients, which was significantly higher than that of healthy controls （10.4 % ） （X^2= 20. 77,P=0. 000,RR=8.57） and those reported in another 2 literatures （23.2%, [N=342, P=0. 000] and 29%, [N=255, P=0. 008]）. The frequency of HLA-DR8 was 22. 5% in PBC patients, which was significantly higher than that of healthy controls （7.5 %, [X^2 = 4. 980, P = 0. 026, RR = 3.60]） and those reported in the other 2 literatures （ 11.2 %, [ N = 342, P = 0. 038] and 10. 2% [N=255, P=0. 025]）. Conclusion： It is suggested that the morbidity of PBC in northern Chinese citizens is associated with HLA-DR7 and DR8. DR7 has not been reported in literatures outside China.