中文摘要：

转录因子GATA结合蛋白4（GATA-binding protein4，GATA4）在心脏发育和心肌重塑过程中发挥重要的调控作用。GATA-4基因缺失可致胚胎死亡，而不同位点的错义突变将引起不同类型的先天性心脏发育畸形。GATA-4蛋白表达水平降低可导致心脏功能进行性下降。压力超负荷、缺氧、交感神经激活等各种心肌肥厚刺激因素均可显著影响GATA-4的DNA结合活性，进而通过调控心房利钠肽（ANP）、脑利钠肽（BNP）、B细胞淋巴瘤因子2（Bcl-2）、心肌锚定重复序列蛋白（CARP）等多种心肌重塑相关转录因子的表达参与心肌重塑过程。深入探讨GATA-4的转录调控机制，有望为心血管疾病的防治提供新的线索。本文扼要综述GATA-4在心脏发育及心肌重塑中的研究现状。

英文摘要：

GATA-4 plays important roles in the process of cardiac development and remodeling. Deletion or mutation of GATA-4 is associated with malformation of cardiac development directly, even embryolethality. Down-regulation of GATA-4 may lead to deterioration of cardiac function. GATA-4 activity is significantly changed by pathological stimulation induced by pressure overload, hypoxia, sympathetic nerve activation, etc. It involves in the process of myocardium remodeling through regulating ANP, BNP, Bcl-2, CARP, etc. Overall, GATA-4 has important roles in the process of cardiac development and remodeling. Exploration of underlying mechanism of GATA-4 transcriptional regulation may provide a new clue for the prevention and treatment of cardiovascular diseases.