中文摘要：

过去的十年见证证据证明那 hypoxic 微型环境，是典型 duringcancer 开发，在调整癌症房间新陈代谢起关键作用的快速的累积。在这评论，特别地，我们将集中于 hypoxicresponse 的角色它的主人管理者组织缺氧可诱导的 factor-1 在调整葡萄糖，在癌症房间的类脂化合物，以及氨基的 acidmetabolism。我们将也由指向特定的小径讨论治疗学的机会在癌症房间的那 facilitatemetabolic reprogramming。

英文摘要：

The past decade has witnessed a rapid accumulation of evi- dence showing that hypoxic microenvironment, which is typical during cancer development, plays key roles in regu- lating cancer cell metabolism. In this review, we will focus on the role of hypoxic response, particularly, its master regulator hypoxia-inducible factor-I, in regulating glucose, lipid, as well as amino acid metabolism in cancer cells. We will also discuss the therapeutic opportunities by targeting specific pathways that facilitate metabolic reprogramming in cancer cells.