苦参素是生物碱类药物,在临床上主要用于慢性肝炎等疾病的治疗。本文综述了苦参素在药理和抗肿瘤方面作用的研究进展,主要包括抗炎、抑菌、降酶、抗病毒、免疫调节、抗肿瘤、抗肝纤维化、抗心律失常、抗过敏和平喘等作用,重点阐述苦参素抗肿瘤作用的机制,对其临床应用和不良反应也进行论述,为该药在临床的进一步应用提供理论依据。
Kushenin (main contains oxymatrien)is a kind of alkaloids and applied in therapy of chronic hepatitis and so on. This paper summarized the pharmacological effects of alkaloids, such as anti-inflammation, anti-bacteria, decrease amiuopherase, antivirus, immunity-regulation, anti-tumor, anti-fibrosis, anti-cardiac-arrhythmias, anti-hypersusceptibility and anti-asthma. This paper emphasize on the mechanism of Kushenin on anti-tumor, its clinical application, and its adverse effect, which may give more help to its application.